Junior Research Group - Chronobiology

Junior Research Group Leader

Dr. Silke Kiessling

Tel.: +49 8161 71 2375

silke.kiessling[a]tum.de

Modern life styles frequently perturbs our endogenous, so called circadian clock. This circadian disruption is considered to be an important contributory factor to the incidence of a wide range of gastrointestinal (GI) pathologies including GI diseases, inflammation and even cancer. This is not surprising because major GI functions, such as mucosal barrier function and the immune system are controlled by the circadian clock. A prominent role of the GI tract relies in its immune defense preventing pathogens from passing the mucosal barrier. Thus, barrier function and a functional GI immune system might be important links between the circadian clock and the development of various pathologies of the GI. Thus, it is important to investigate whether local GI clock disruption favors pathology of GI diseases. By generating a novel transgene mouse model the impact of the GI circadian clock will be examined on the pathogenesis of gastrointestinal diseases, such as IBD, on molecular and physiological levels in vivo.

  1. Uetani N., Hardy S., Gravel SP. Kiessling S., Pietrobon A., Wong NN., Chénard V., Cermakian N., ST-Pierre J., and Tremblay ML., “PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms.” JCI Insight, 2017 July 6;2(13):e91722, Manuscript in press.
     
  2. Kiessling S., Ucar A., Chowdhury K., Oster H. and Eichele G., "Background specific effects of micro RNAs on circadian clock function.", PLoS ONE,  2017 April 27;12(4):e0176547.
     
  3. Kiessling S., O'Callaghan E., Freyburger M., Cermakian N. and Mongrain V., The cell adhesion molecule EphA4 is involved in circadian clock function and light suprachiasmatic nucleus.” Genes, Brain and Behavior, 2017 April 20.
     
  4. Kiessling S., Beaulieu-Laroche L., Blum I., Landgraf D., Welsh D.K., Storch K.F., Labrecque N. and Cermakian N., "Activating circadian clock function in cancer cells inhibits tumor growth ", BMC Biology, 2017 Feb 14;15(1):13.
     
  5. Cermakian N., Westfall S. and Kiessling S. "Circadian clocks and inflammation: reciprocal regulation and shared mediators", Archivum Immunologiae et Therapiae Experimentalis (AITE) 2014 Aug; 62(4):303.
     
  6. Kiessling S., Sollars P.J. and Pickard G.E., "Light stimulates the mouse adrenal through a retinohypothalamic pathway independent of an effect on the clock in the suprachiasmatic nucleus", PLoS ONE, 2014. 9(3).
     
  7. Kiessling, S., Eichele G., and Oster H., "Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag." J Clin Invest, 2010. 120(7).
     
  8. Oster, H., Damerow, S., Kiessling, S., Jakubcakova, V., Abraham, D., Tian, J., Hoffmann, M. W. And Eichele, G.et al., "The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock." Cell Metab. 2006 4(2).
     
  9. Kiessling S. & Cermakian N. Circadian clocks and cancer", In: Biological Timekeeping: Clocks, Rhythms and Behaviour, Ed. V. Kumar, Springer, Chapter 23, in press. (Book Chapter)
     
  10. Nobis, C., Kiessling, S., Labrecque, N., Cermakian, N. (2015) Circadian clocks and immune functions. In: Biological Timekeeping: Clocks, Rhythms and Behaviour, Ed. V. Kumar, Springer, Chapter 22, in press. (Book Chapter)
     
  11. Kiessling S, "Functional Analysis of the Adrenal circadian Clock Adrenal Clock lags Jet Lag", Suedwestdeutscher Verlag fuer Hochschulschriften, 2011 (Book)