Junior Research Group - Chronobiology

Junior Research Group Leader

Dr. Silke Kiessling

Tel.: +49 8161 71 2375

silke.kiessling[a]tum.de

Modern life styles frequently perturbs our endogenous, so called circadian clock. This circadian disruption is considered to be an important contributory factor to the incidence of a wide range of gastrointestinal (GI) pathologies including GI diseases, inflammation and even cancer. This is not surprising because major GI functions, such as mucosal barrier function and the immune system are controlled by the circadian clock. A prominent role of the GI tract relies in its immune defense preventing pathogens from passing the mucosal barrier. Thus, barrier function and a functional GI immune system might be important links between the circadian clock and the development of various pathologies of the GI. Thus, it is important to investigate whether local GI clock disruption favors pathology of GI diseases. By generating a novel transgene mouse model the impact of the GI circadian clock will be examined on the pathogenesis of gastrointestinal diseases, such as IBD, on molecular and physiological levels in vivo.